Na data nke III nke China na-eme nke ọma na neji na-egosi adịghị ike na paxlovid

N'ime awa ole na ole nke 29 Decempo na 29, Nejm bipụtara n'ịntanetị bụ usoro ụlọ ọgwụ ọhụrụ III nke Counonavirus ọhụrụ VV116. Nsonaazụ gosiri na VV16 abụghị njọ karịa PAXLOVID (Nematovir / riteonavir) na usoro nke oge na-agbake ma na-eme obere ihe.

Isi mmalite: Nejm

Oge mgbake nke Median ụbọchị 4, ụda ihe omume 67.4%

VV116 bụ nucleoside na-eme ọhụụ (carrs-CoVivir na Gilead na-emekọrịta ihe, Marck dị nkọ na ezigbo moolnuduvine.

Na 2021, a na-eme usoro ikpe ọgwụ nke VV116 na Uzbekistan. Nsonaazụ nke ọmụmụ ahụ gosiri na VV116 nwere ike ime ka ihe mgbaàmà nke ụlọ ọrụ wee belata ohere nke ọganihu dị oke mkpa na ọnwụ ma e jiri ya tụnyere ndị otu njikwa. Ezubere nsonaazụ nke ikpe a, a na-anakwere VV116 maka ọgwụgwọ nke ihe ndị ọrịa na-enwe oke ọgwụ maka ịkọ nkọ maka ire ahịa na mba ofesi na China [1].

Usoro ikpe a III (NTT0534161616161616) Na-enyocha nrụpụta na nchekwa nke vv116 versus paxlovid maka ọgwụgwọ nke ndị ọrịa nwere ịdị nwayọọ ruo n'ọchị-19. Ebumnuche ahụ bụ ịtụle arụmọrụ na nchekwa nke vv116 versus paxlovid maka ọgwụgwọ nke ndị ọrịa nwere ịdị nwayọọ ruo n'ọchị-19.

Isi mmalite: Roomple 2

A na-eme ọtụtụ ihe, na-ahụkarị, na-ekwu okwu, na-achịkwa, na-achịkwa ya nke 822 na-achịkwa ihe mgbaàmà dị egwu na ihe mgbaàmà dị iche iche nke ndị sonyere na Shanghai, China. N'ikpeazụ, ndị sonyere na-enweta VV116 (384, 600 mg awa iri na abụọ na ụbọchị 2 na 3 mg ritenovavir kwa awa iri na abụọ maka ụbọchị 5) dị ka ọgwụ.

Nsonaazụ nke ọmụmụ ihe a gosipụtara na usoro ọgwụgwọ VV116 maka ịdị nwayọọ na-eme ka ọ bụrụ ụbọchị 4 na-ebugharị na-agbake). 95% ci, 1.02 na 1.36; 0.8).

Nọgide na-agbazi oge ezumike

Mmebi iwu na nke abụọ na-arụ ọrụ (nyocha zuru oke nke ndị bi)

Isi mmalite: Roomple 2

N'usoro nchekwa, ndị sonyere na-akọ akụkọ vv116 kọrọ na ole na ole (77.3%) na-agbaso vv116 (2.6%) karịa PAXLOVID (5.7%).

Ihe Ọjọ Omume (Ndị Na-adịghị mma)

Isi mmalite: Roomple 2

Esemokwu na ajụjụ

Na Mee 23, 2022, Juniper kwupụtara na usoro akwụkwọ nyocha nke VV116 vertus PAXLID maka mmeghe nke ọdịda dị nro - 19 (Nct053416) mezuru njedebe ọmụmụ ya.

Isi mmalite: Roopụta 1

N'oge a na-enweghị nkọwa nke ikpe ahụ, esemokwu gbara gburugburu na-eme ihe nkiri nke III bụ iri abụọ, ọ ga-esiri ya ike ikpe ọgwụ ahụ kpamkpam; Nke abuo, enwere ajuju banyere ogwu ogwu.

Clinical incious Clition maka Junipa bụ (m) Ngosipụta dị mma maka nnwale nke okpueze ọhụrụ, (III) na-adịghị mma ma ọ bụ karịa ihe ize ndụ nke oke ọgbụgba na-egbu egbu - 19, gụnyere ọnwụ. Agbanyeghị, naanị otu ụlọ ọgwụ bụ isi nke bụ 'oge iji kwadoweghachite ụlọ ọgwụ'.

Tupu ọkwa ahụ, na Mee 14, Junipa agbagharịla usoro ọgwụ site na iwepu otu ebe njedebe nke ụlọ ọgwụ, "nke mgbanwe nke mkparịta ụka siri ike na ọrịa ma ọ bụ ọnwụ" [3].

Isi mmalite: Roopụta 1

A na-akpọkwa isi ihe abụọ a na nnọkọ na ọmụmụ ihe e bipụtara.

N'ihi mgbawa mberede nke Omicron, imepụta mbadamba akwụkwọ Ebe PAXLOVID tupu mmalite nke ikpe ahụ na ya mere na ndị nchọpụta ahụ enweghị ike iduzi ikpe a site na iji akara ngosi abụọ. Banyere otu akụkụ nke onye na-ahụ maka ikpe ahụ, Juniper kwuru na a na-eduzi Protocol mgbe ị na-eme nnyocha na-egosi na ọ bụ onye na-ahụ maka akwụkwọ nyocha ahụ.

Ruo oge nyocha ikpeazụ, ọ dịghị onye ọ bụla n'ime ule ahụ enwewo ọnwụ ọnwụ ma ọ bụ na-egbochi esemokwu siri ike ma ọ bụ ọnwụ. Ihe omuma a gosiputara na oge atumatu nke uche site na usoro ihe mgbaàmà nke na - eme ka ọ bụrụ ụbọchị asaa (95)) na 95% ci, 0.91 ruo 1.22) [2]. O sighị ike ịkọwa ihe kpatara njedebe nke ntụgharị nke mgbanwe siri ike ma ọ bụ ọnwụ ', nke e setịpụrụ tupu ọgwụgwụ nke ikpe ahụ, wepụrụ.

Na 18 Mee 2022, akwụkwọ akụkọ ahụ na-ebipụta ngwaọrụ na-ebipụta nsonaazụ nke nnwale nke VV116 na ndị ọrịa na-ebute Ochie, ọmụmụ ihe na-emeghe na 136.

Data site na ọmụmụ ahụ gosipụtara na ọrịa Omicron na-eji VV116 n'ime ụbọchị 5 nke ụbọchị ise ha na-emegharị nke 8.56, na-erughị ụbọchị 11.13 na otu njikwa. Nchịkwa nke VV116 ka ndị ọrịa Symplactom nke ọmụmụ a (ụbọchị 2-10 nke mbụ dị mma) belatara oge a na-ebugharị na ndị ọrịa niile. N'ihe banyere nchekwa ọgwụ ọjọọ, enweghị nnukwu mmetụta ọjọọ ka a hụrụ otu vv116.

Isi mmalite: Roopụta 4

E nwere ọnwụnwa atọ na-aga n'ihu na VV116, nke abụọ na-akpata akwụkwọ na-amụ akwụkwọ na-eme nnyocha-19 (NTT02422222082629). Ọnwa ọzọ na-agafekarị oke na oke mkpuchi - 19 bụ ihe na-enweghị isi, na-enweghị isi, okpukpu abụọ, abụọ kpuru ìslọ ọgwụ (Nct027) iji nyochaa nrụpụta nke vv116 ma e jiri ya tụlee ọgwụgwọ. Dabere na ọkwa nke Junipa, e debara aha onye ọrịa mbụ ma debe ya na March 2022.

Isi mmalite: ụlọ ọgwụ.gov

Ntuziaka:

[1] Junenni Biotech: Nkwupụta na isi mmalite nke usoro ụlọ ọgwụ nke VV116 versus PAXLID PAXLID maka ọgwụgwọ dị nro

[2] https://www.nejm.org/doi/DEJEL/10SEL/ReCEYS.gov/c05534161616161616161616161616161616161616116161616161616161616161616161616161616161616161616161616161616116095k2/dov/cars.gov/shoow [3] Zheng, xiagwang GAO, nje na-egbu, ma, ọ na-acha uhie uhie, na-acha uhie uhie, na-acha uhie uhie, jenhong Zhang, zhengxin Wang. (2022) profaịlụ Omecron na ọnọdụ ịgba ọgwụ mgbochi n'etiti 1881 imeju afọ iri na asatọ: A na-echegharị obere ụlọ. Ngwándị ụmụ nje & ọrịa 11: 1, peeji 2636-264.